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All About JNK Antibody

The stress-activated protein kinase/Jun-amino-terminal kinase SAPK/JNK is potently and preferentially activated by a variety of environmental stresses including UV and gamma radiation, ceramides, inflammatory cytokines, and in some instances, growth factors and GPCR agonists. Similar to the other MAPKs their signaling unit is made up of a MAPKKK.

When activated, MKKs phosphorylate and activate the kinase SAPK/JNK. Stress signals are transmitted to this cascade through small GTPases from the Rho family. Each Rac1 and cdc42 plays a role in their stimulation to MEKKs as well as MLKs. You can know more about JNK antibodies via www.bosterbio.com/anti-jnk1-antibody-pa1892-boster.html.

Additionally, MKK4/7 may be activated via a GTPase independent mechanism by stimulating germinal center-kinase (GCK) one of the family members. Three SAPK/JNK genes are present, each of which undergoes alternate splicing, which results in a variety of forms. SAPK/JNK when activated as a dimer moves to the nucleus and control transcription through its influence on c-Jun ATF-2, c-Jun, and other transcriptional components.

C-Jun's N-terminal Kinase (JNK) is also referred to as Mitogen-activated Protein Kinase (MAPK8). It is part of the MAPK superfamily of protein kinases activated by stress. MAPKs are Serine-threonine kinases that can be activated in response to numerous extracellular triggers and are involved in signal transfer from the cell's at the surface into the nucleus. 

JNK can be found in a variety of cell-related processes like the proliferation of cells and differentiation, transcription regulation, and development. JNK channels are activated when stressed or inflammatory signals. JNK is expressed in 10 different forms due to the different splicing of mRNA. The most common JNK isoforms comprise JNK1 as well as JNK2.